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How many women misunderstand?

It is speculated that one quarter of known pregnancies end in abortion, because many women miscarry before they realize they are pregnant, so half of pregnancies end in abortion. For women who have miscarried twice or more, 70% continue to have healthy babies. Because of fetal chromosomal abnormalities, most miscarriages are likely to occur in the early stages of pregnancy. Half of the cases of repeated abortions were not explained.

For most women, the chance of successful pregnancy is 80%. Women under 35 are about one in six likely to miscarry again. For every 100 women trying to conceive, one miscarried more than three times. Suppose you have had two or more miscarriages. In this case, it may be necessary to meet fertility experts in reproductive endocrinology and infertility. He can help you find out why you have repeated miscarriages and what you plan to do.

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What caused the miscalculation?

Common Myths about the Wuchang

How to reduce the risk of accidental injury

What is the MTMF reductase mutation? What is the relationship between it and homocystine?

What role does MTMF reductase mutation play?

What else can we do to increase homocystine levels?

Is there MTHFR mutation test?

How to treat MTHFR mutation?

What is folic acid(folic acid)? What effect does it have on pregnancy?

More Folic Acid Sources

How does the body use folic acid?

Can testosterone cause abortion?

Can injection of progesterone prevent abortion?

What should I do now?

What caused the miscalculation?

Look for the cause of abortion? Biological factors include women over 35 years of age or male spouses over 40 years of age, embryonic genetic defects or uterine abnormalities.

Lifestyle factors include too light weight, too light, smoking every day ½ This may include taking facial mask or more, drinking alcohol, taking cocaine or often weighing more than 220 pounds.

Uncontrolled diabetes, hypertension, thyroid disease, lupus or other autoimmune diseases, coagulation problems, sexually transmitted infections and other health factors will increase the risk.

Environmental factors may include heavy metal exposure, some drugs, stress, etc.

Coagulation disorders may include diseases that increase the risk of miscarriage – anti cognitive antibodies, factor V Leiden, and lupus anticoagulants. In addition, low or high oxytocin values may increase the risk of miscarriage. Learn more about oxytocin.

Common Myths about the Wuchang

although it is generally believed that this series of activities has nothing to do with heritage.

General sports activities, full-time work, standing for more than 6 hours every day, screen time, air travel, sex, caffeine, fetal room, contraceptives, influenza vaccine and novel coronavirus vaccine.

How to reduce the risk of accidental injury

Reducing the risk of recurrent miscarriage is the recovery of your body and mood. Talk with your doctor about your future pregnancy time, get rid of bad habits, control chronic medical problems, maintain a healthy weight, reduce caffeine to one cup every day, and treat your possible deficiencies.

What is the MTMF reductase mutation? What is the relationship between it and homocystine?

Recently, MTMF reductase gene mutation has attracted much attention. This is methylenetetrahydrofolate reductase, which is required for the metabolism of folic acid. Folic acid is necessary to build DNA and reduce the level of isotype stainless steel in blood. Mutation of MTMF reductase gene will reduce the enzyme activity and increase the value of isotype stainless steel.

Homocystine increased, blood coagulation and platelet aggregation. Platelets are tiny blood cells that gather together to form clots in your body. This happens frequently, but is usually strictly controlled. The same type of stainless steel damages the inner layer of blood vessels, platelet aggregation and blood coagulation. Coagulation in the placenta can cause damage or loss of pregnancy.

The two most common MTMF reductase mutations are C677T and A1298C variants. Health problems are associated with the 677 variant. This happened to almost half of Americans. About a quarter of Hispanics and one sixth of Caucasians are homozygous for this gene, which means that their parents have genetic defects. Heterozygosity means you have only one gene. Both genes are defective, worse than one. The 1298 variant will hardly cause problems. It is found that 7~14% of North Americans, Europeans and Australians are less common among Hispanics and Asians.

What role does MTMF reductase mutation play?

MTMF reductase mutations are also associated with fetal liver failure, anemia, neural tube defects and abortion. Some people think it is related to depression, schizophrenia and double affective disorder, but these have not been proved to be caused by gene mutation.

What else can we do to increase homocystine levels?

Other reasons for improving the value of isotype stainless steel include hypothyroidism, diabetes, high cholesterol, hypertension, obesity, sofa potato lifestyle, atorvastatin and vitamins. The others need not be mentioned.

Is there MTHFR mutation test?

American Obstetrics and Gynecology(ACOG) does not recommend to check the MTMF reductase gene, unless the value of isotype stainless steel increases. However, if you want, you can conduct a family test with a commercial gene company(such as 23andMe. com) for about $200. Another test of Empower Dx can be obtained for $80: “MTHFR at home”.

How to treat MTHFR mutation?

MTHFR gene mutation therapy during pregnancy may include alicin restricted diet, 100mg aspirin a day, daily vitamins B1, B2, B3, B6, B9 and B12, 5mg folic acid twice a week and blood thinner Lovenox. But even genetic defects will not occur completely in a vacuum. Other factors we mentioned above will also affect pregnancy health.

What is folic acid(folic acid)? What effect does it have on pregnancy?

Tablets containing b9 folic acid. Dietary supplements. Vitamin capsules. 3D

Pregnancy can increase the demand for folic acid. We can regularly supplement folic acid in the first few months of pregnancy to reduce neural tube defects of spina bifida or anencephaly, which has become very important.

More sources of folic acid: broccoli, spinach, lettuce, fruits and nuts, cooked beans, peas, lentils, asparagus, corn, many bread, flour, rice and cereal products are rich in folic acid, guava, melon seeds, cantaloupe, wheat syrup, bananas, raspberries, grapefruit, strawberries

Fruit juice: orange, pineapple, grapefruit, tomato or other vegetables, peanut butter, melon seeds, avocado.

How does the body use folic acid?

Your body metabolizes folic acid of food into active form THF and tetrahydrofolic acid. Our body cannot produce folic acid. Folic acid is often called a vitamin B9 supplement. Folic acid is converted into the active form of 5-MTMF in the intestinal tract, as is the case with the liver, but it takes some time. Even in small amounts, the body may not fully metabolize when taking the next drug. But taking other B vitamins can improve the conversion rate. By the way, folic acid or B9 is a water-soluble vitamin. This is something you don’t need This means that it is excreted by urine. You can’t store it in your body, so you must take it every day. By the way, “vitamin” comes from the concept of “important amine” in the body. We can’t make it, so we should supplement it.

Folic acid and/or B12 can be taken when there is MTHFR mutation or high homozygosity due to folic acid or vitamin B12 deficiency. Some people think that the methylation form of folic acid is better for the body, but even if there is a gene mutation, you can also take folic acid. There is evidence that the body is better at using the L-methylfolic acid form. The methylated form is called 5-MTHF, which can also be obtained through L-folic acid calcium or L-folic acid magnesium. It is sold online as methoxycillin, difluoracillin, Enlit, etc.

Can testosterone cause abortion?

Low oxytocin levels are associated with miscarriage, but it has not been determined whether this is the real cause. Puerarin supplementation seems to reduce the number of miscarriages in patients with multiple miscarriages. This name is due to its fertility promoting activity. It is the main hormone that supports pregnancy. When the ovaries ovulate and release the eggs, the remaining corpus luteum produces ketones. If there is no pregnancy, it will disappear. After pregnancy, ketone production will be supported until 7 to 9 weeks of pregnancy. The placenta then takes over the production of ketones and estrogen.

Can injection of progesterone prevent abortion?

Ten scientific studies involving nearly 1700 women have found appropriate evidence of the benefits of taking flavonoids. However, there is no general consensus on the use of steroids for recurrent abortion. No studies have shown that ketone supplementation increases birth defects. The substitute of dydrogestone seems to have no adverse effect on infants, but there are still many problems about how to use it best.

As we all know, low progesterone is usually the cause of repeated abortions, but the most common case is that low progesterone levels are a symptom of unhealthy pregnancy. For example, embryos may have low levels of β – HCG. β – hCG triggers the production of oxytocin and estrogen. Low levels of β – HCG can induce low levels of oxytocin. However, the lower β – HCG may be caused by the abnormality of embryonic chromosome. In this case, oxytocin supplementation does not repair potential chromosomal abnormalities.

It is difficult to determine what level of oxytocin will lead to a healthy pregnancy. It is clear that a blood sample to check the ketone level is completely unknown. Your fertility specialist can help you solve this problem. Oxytocin is essential for in vitro fertilization(IVF). Because the eggs harvested from IVF do not have normal corpus luteum, they usually produce oxytocin. Ketone value and β – hCG value are helpful to predict healthy pregnancy.

What should I do now?

A legacy can be devastating, and it is difficult to leave it alone. Many factors can cause this. Talking to an OB/GYN is the first step to a healthy pregnancy. If necessary, you can go to a fertility specialist to help with a healthy pregnancy.

Please remember that abortion is not your fault and cannot be controlled, but you and your obstetrician and gynecologist can try to improve your chances of successful pregnancy.

For your health and pregnancy,

Kevin McCurry, MD